Wrinkles are a natural part of aging, most prominent on sun-exposed skin, such as the face, neck, hands and forearms. Some factors affect when and where people will develop wrinkles, skin-resurfacing techniques, fillers, injectables, sun damage, smoking, dehydration, some medications, and environmental and genetics all play a roll. Most basic wrinkle treatments such as topical retinoid creams tend to help reduce the fine lines. For deeper creases, there are more aggressive techniques, such as injections of fillers as well as skin resurfacing techniques. A combination of these are used for best results.